Pakafukufuku wovuta kwambiri wofalitsidwa mu Biocatalysis ndi Agricultural Biotechnology, ofufuza agwiritsa ntchito bwino njira zosinthira majini kuti apange mbatata zosasinthika zokhala ndi α-solanine, steroidal glycoalkaloid yomwe imatha kukhala poizoni kwa anthu ikadyedwa mochuluka. Kupambana kumeneku kungathe kusintha kalimidwe ka mbatata ndikuwonjezera chitetezo cha chakudya.
Mbatata, mbewu yayikulu padziko lonse lapansi, imatulutsa mwachilengedwe ma steroidal glycoalkaloids awiri: α-solanine ndi α-chaconine. Ngakhale kuti mankhwalawa amagwira ntchito ngati njira zodzitetezera ku zomera, amatha kukhala ndi thanzi labwino akagwiritsidwa ntchito mopitirira muyeso. Zinthu monga kuyatsa, kuwonongeka kwa thupi, komanso kusungidwa kosayenera kungayambitse kuchuluka kwa glycoalkaloids mu mbatata, ndikuwonjezera kuopsa kwa thanzi.
Kuti athane ndi vutoli, ofufuza ochokera ku India adagwiritsa ntchito njira yosinthira ma gene CRISPRI/dCas9-KRAB kupondereza jini ya solanidine galactosyltransferase (sgt1) mu mbatata. Poyang'ana jini yeniyeniyi, ofufuza adatha kuchepetsa kwambiri milingo ya α-solanine mu mbatata ya transgenic, ndikusiya milingo ya α-chaconine osakhudzidwa. Njira yowunikirayi imatsimikizira kuti mbatata imakhalabe yotetezeka kuti idyedwe ndikusunga njira zawo zodzitetezera ku tizirombo ndi matenda.
Chofunika kwambiri, kusanthula zakudya za mbatata zosinthidwa jini sikunawulule kusintha kwakukulu poyerekeza ndi mbatata wamba. Izi zikutanthauza kuti mbatata ya transgenic imakhalabe ndi thanzi komanso kapangidwe kake, ndikupangitsa kuti ikhale njira yabwino komanso yotetezeka kwa ogula.
Zotsatira za kafukufukuyu zili ndi tanthauzo lalikulu pa tsogolo la kulima mbatata. Pochepetsa bwino milingo ya α-solanine kudzera mukusintha ma gene, ofufuza akonza njira yopangira mitundu ya mbatata yabwino yomwe mwachibadwa imakhala yotetezeka kuti anthu adye. Kupambanaku sikungokhudza kuopsa kwa thanzi komwe kumakhudzana ndi glycoalkaloids komanso kumatsegula mwayi watsopano wopititsa patsogolo kadyedwe kabwino ka mbatata.
Zotsatira za kafukufukuyu zayambitsa kale kufufuza ndi chitukuko cha mbatata zosinthidwa ndi majini. Asayansi ndi akatswiri azaulimi tsopano akuyesetsa kukonza ndi kukulitsa zotsatira zoyambilirazi, ndi cholinga chachikulu chopanga mitundu yosiyanasiyana ya mbatata yosinthidwa ndi majini yomwe imapereka zinthu zabwino, kuphatikiza kuchepa kwa glycoalkaloid, kukulitsa zakudya zopatsa thanzi, komanso kukana kwa tizirombo. ndi matenda.
Kugwiritsa ntchito bwino njira zosinthira ma gene kuti apange mbatata ya transgenic yokhala ndi milingo yotsika ya solanine imayimira gawo lalikulu m'munda wa mbatata. Kupambanaku sikungothetsa ziwopsezo zomwe zingachitike paumoyo wokhudzana ndi kumwa mopitilira muyeso wa glycoalkaloid komanso zimatsegulira njira yopangira mitundu ya mbatata yotetezeka komanso yopatsa thanzi. Pamene kafukufuku m'derali akupita patsogolo, titha kuyembekezera tsogolo lomwe mbatata zosinthidwa ndi majini zimagwira ntchito yofunika kwambiri poonetsetsa kuti chakudya chili ndi chakudya komanso kulimbikitsa madyedwe abwino.